May 10, 2023
PHILADELPHIA, May 10, 2023 – SwanBio Therapeutics, a gene therapy company advancing AAV-based therapies for the treatment of devastating, inherited neurological conditions, has conducted a healthcare resource use study confirming the substantial burden and economic impact of AMN on both men and women.
“The real-world data we have gathered illuminate the under-acknowledged burden of AMN: affected individuals are experiencing more comorbidities, higher rates of hospitalization, substantially more prescription fills, higher overall healthcare costs, and poorer clinical outcomes than their peers,” said Tom Anderson, chief executive officer and director, SwanBio Therapeutics. “These findings demonstrate that the standard of care for AMN is not enough – these patients need and deserve more.”
SwanBio’s study was based on a retrospective review of commercial insurance and Medicare claims, comparing resource utilization and health outcomes of men and women living with AMN to those without AMN from similar demographic groups.
Key findings include:
These findings were recently presented at the American Academy of Neurology (AAN) Annual Meeting and International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Annual Meeting. For more information, visit swanbiotx.com/investors-and-media/events-and-presentations/.
Adrenomyeloneuropathy (AMN) is a progressive and debilitating neurodegenerative disease caused by mutations in the ABCD1 gene that disrupt the function of spinal cord cells and other tissues. AMN is characterized by loss of mobility in adulthood, incontinence, pain, and sexual dysfunction, which all affect quality of life. Patients often experience adrenal gland dysfunction as well. Between 8,000-10,000 men in the United States and EU5 (France, Germany, Italy, Spain, and the United Kingdom) are living with AMN. There are no approved therapies for the treatment of the disease; current standard of care is limited to symptom management.
SBT101 is the first clinical-stage adeno-associated virus (AAV)-based gene therapy candidate for people with adrenomyeloneuropathy (AMN). In preclinical studies, treatment with SBT101 demonstrated dose-dependent improvement of disease markers and functional improvement in AMN mouse models. SBT101 was also shown to be well-tolerated in non-human primates through six months post-treatment. The ongoing clinical program for SBT101 builds on this positive preclinical data, plus SwanBio’s deep understanding of the underlying pathophysiology of AMN and the AMN patient experience, including new insights being gathered in a proprietary natural history study, CYGNET.
SBT101 has been granted Fast Track and Orphan Drug Designation from the U.S. Food and Drug Administration and Orphan Drug Designation from the European Medicines Agency.